Overview

Gammabenzene and citrimide combination is available in the form lotions and creams. Gammabenzene is used to treat skin infections with symptoms like continuous itching and used to treat lice infections whereas Cetrimide is an antiseptic and disinfectant which is a mixture of different quaternary ammonium salts including cetrimonium bromide and is used as topical disinfectant used in various skin preparations.

Indications

• It is used to treat Scabies who have failed to respond to other therapies
• Patients suffering from lice infection.
• Used topically for cleansing of wounds
• Treatment of some skin disorders
• Minor burns
• Small wounds

Mechanism of Action

Gammabenzene exerts its parasiticidal effect by being directly absorbed into the parasite (primarily lice or scabies) and their ova. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system, resulting in convulsions and death.
Cetrimide is a cationic surfactant. It destroys or damages the cell membrane by lowering surface tension. It causes microbial protein denaturation and produces antiseptic action. It has bactericidal activity against gram-positive bacteria.

Side Effects

• Itching skin
• Burning sensation
• Dry skin
• Rashes

Contraindication

• Very young infants
• Patients with extensively excoriated skin.

Storage

• Store at room temperature
• Protect from direct heat and light.